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The “Immune-microenvironment interactions in health and disease” team is recruiting a study/research engineer to support research in fundamental immunology and bioengineering of immunocompetent organoids and 3D models.
Here we propose to study and target the RUVBL1 and RUVBL2 chaperones, which are HSP90 cofactors with negative prognostic value and frequently overexpressed in CRC tumours. These proteins form a hetero-hexameric complex that carries AAA+ ATPase activity and they recently emerged as a novel chaperone for several multimeric complexes involved in cell proliferation.